Iran launches retaliatory strikes as Trump calls for regime change

The U.S. and Israel have launched strikes on Tehran, and President Donald Trump says the U.S. is starting major combat operations against Iran. Witnesses reported smoke near offices tied to Iran’s supreme leader on Saturday, and residents hear heavy explosions across the capital. Trump says Iran keeps pursuing nuclear work and missile development, and he warns U.S. casualties are possible. Iran says it has not enriched uranium since June, but it has blocked international inspectors from bombed sites. The Associated Press says satellite images show new activity there. Iraq closes its airspace, and Israel also shuts its airspace.